Effect of Peroxiredoxin 1 on the biological function of airway epithelial cells and epithelial-mesenchymal transition

Peroxiredoxin 1 (PRDX1) participates in tumor cell proliferation, apoptosis, migration, invasion, and the epithelial-to-mesenchymal transition (EMT). This study aimed to investigate effect of PRDX1 on EMT airway epithelial cells stimulated with lipopolysaccharide (LPS) transforming growth factor-beta (TGF-β1). overexpression significantly increased proliferation migration human bronchial (BEAS-2B) cells, reduced apoptosis (p < 0.01), induced collagen deposition by upregulating expression matrix metallopeptidase (MMP)2, MMP9, α-smooth muscle actin (α-SMA), N-cadherin, vimentin twist proteins inhibiting E-cadherin 0.05). promoted TGF-β1-mediated inhibition enhanced TGF-β1-induced synthesis Knockdown inhibited EMT, reversed LPS-mediated suppressed LPS-induced 0.01). The result indicating that may be involved LPS/TGF-1-induced cells.